| # | Player | Pos | Team | Average Separation | SF Value |
|---|---|---|---|---|---|
| 1 | Luther Burden | WR | CHI | 4.6 | 2,269 |
| 2 | Evan Engram | TE | DEN | 4.6 | 43 |
| 3 | Marvin Mims | WR | DEN | 4.5 | 112 |
| 4 | AJ Barner | TE | SEA | 4.1 | 353 |
| 5 | DeMario Douglas | WR | NE | 3.9 | 25 |
| 6 | Brenton Strange | TE | JAX | 3.9 | 506 |
| 7 | Chig Okonkwo | TE | WAS | 3.9 | 220 |
| 8 | John Metchie | WR | CAR | 3.8 | 68 |
| 9 | Khalil Shakir | WR | BUF | 3.8 | 359 |
| 10 | Chimere Dike | WR | TEN | 3.8 | 227 |
| 11 | Jonnu Smith | TE | FA | 3.8 | 40 |
| 12 | Dalton Schultz | TE | HOU | 3.8 | 188 |
| 13 | T.J. Hockenson | TE | MIN | 3.8 | 191 |
| 14 | Colston Loveland | TE | CHI | 3.7 | 3,390 |
| 15 | George Kittle | TE | SF | 3.7 | 664 |
| 16 | Malik Washington | WR | MIA | 3.7 | 68 |
| 17 | Juwan Johnson | TE | NO | 3.7 | 148 |
| 18 | Dawson Knox | TE | BUF | 3.6 | 16 |
| 19 | Cole Kmet | TE | CHI | 3.6 | 52 |
| 20 | Tre Tucker | WR | LV | 3.6 | 86 |
| 21 | Rashee Rice | WR | KC | 3.6 | 3,017 |
| 22 | Jake Tonges | TE | SF | 3.6 | 124 |
| 23 | Zay Flowers | WR | BAL | 3.6 | 2,391 |
| 24 | Colby Parkinson | TE | LAR | 3.6 | 70 |
| 25 | Kyle Pitts | TE | ATL | 3.6 | 1,524 |