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| # | Player | Pos | Team | Yards Per Route Run | SF Value |
|---|---|---|---|---|---|
| 1 | Jaxon Smith-Njigba | WR | SEA | 4.4 | 8,457 |
| 2 | Dalton Kincaid | TE | BUF | 4.0 | 588 |
| 3 | Stefon Diggs | WR | WAS | 3.5 | 336 |
| 4 | DeMario Douglas | WR | NE | 3.1 | 25 |
| 5 | Luther Burden | WR | CHI | 3.1 | 3,105 |
| 6 | Zay Flowers | WR | BAL | 3.0 | 3,084 |
| 7 | Christian Watson | WR | GB | 2.9 | 1,100 |
| 8 | Terry McLaurin | WR | WAS | 2.7 | 1,079 |
| 9 | Amon-Ra St. Brown | WR | DET | 2.6 | 6,986 |
| 10 | Nico Collins | WR | HOU | 2.6 | 3,625 |
| 11 | Greg Dulcich | TE | MIA | 2.6 | 40 |
| 12 | George Pickens | WR | DAL | 2.6 | 4,484 |
| 13 | CeeDee Lamb | WR | DAL | 2.6 | 6,000 |
| 14 | Malik Nabers | WR | NYG | 2.5 | 6,138 |
| 15 | Drake London | WR | ATL | 2.4 | 5,345 |
| 16 | Rashee Rice | WR | KC | 2.4 | 3,015 |
| 17 | Khalil Shakir | WR | BUF | 2.4 | 326 |
| 18 | Parker Washington | WR | JAX | 2.4 | 1,532 |
| 19 | A.J. Brown | WR | NE | 2.4 | 3,123 |
| 20 | Darren Waller | TE | CAR | 2.3 | 20 |
| 21 | Chris Olave | WR | NO | 2.3 | 3,655 |
| 22 | Ja'Marr Chase | WR | CIN | 2.3 | 9,557 |
| 23 | Keenan Allen | WR | IND | 2.2 | 157 |
| 24 | Tucker Kraft | TE | GB | 2.2 | 2,408 |
| 25 | Alec Pierce | WR | IND | 2.2 | 973 |