| # | Player | Pos | Team | Rushing EPA | SF Value |
|---|---|---|---|---|---|
| 1 | Jonathan Taylor | RB | IND | 18.8 | 5,065 |
| 2 | Blake Corum | RB | LAR | 15.9 | 724 |
| 3 | D'Andre Swift | RB | CHI | 15.4 | 975 |
| 4 | De'Von Achane | RB | MIA | 14.0 | 5,858 |
| 5 | Javonte Williams | RB | DAL | 12.2 | 2,046 |
| 6 | Rachaad White | RB | WAS | 10.4 | 313 |
| 7 | Kareem Hunt | RB | FA | 9.7 | 54 |
| 8 | Derrick Henry | RB | BAL | 9.2 | 1,569 |
| 9 | TreVeyon Henderson | RB | NE | 8.5 | 3,358 |
| 10 | Tank Bigsby | RB | PHI | 7.2 | 169 |
| 11 | Chris Rodriguez | RB | JAX | 6.2 | 143 |
| 12 | James Cook | RB | BUF | 5.6 | 4,831 |
| 13 | Kyren Williams | RB | LAR | 4.9 | 2,447 |
| 14 | Audric Estime | RB | NO | 4.7 | 82 |
| 15 | J.K. Dobbins | RB | DEN | 4.2 | 422 |
| 16 | Kyle Monangai | RB | CHI | 3.7 | 851 |
| 17 | Ty Johnson | RB | BUF | 2.8 | 14 |
| 18 | Keaton Mitchell | RB | LAC | 2.6 | 151 |
| 19 | Terrell Jennings | RB | NE | 2.4 | 10 |
| 20 | British Brooks | RB | HOU | 2.2 | 0 |
| 21 | Corey Kiner | RB | ARI | 1.9 | 0 |
| 22 | Trayveon Williams | RB | CLE | 1.6 | 0 |
| 23 | Jaleel McLaughlin | RB | DEN | 1.6 | 14 |
| 24 | Roschon Johnson | RB | CHI | 1.4 | 17 |
| 25 | Jeremy McNichols | RB | WAS | 1.4 | 13 |